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1. (WO2018165822) SULFONAMIDE COMPOUNDS AND PREPARATION METHOD THEREFOR, AND USE OF SAME AS URATE TRANSPORTER INHIBITOR MEDICINES
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Pub. No.: WO/2018/165822 International Application No.: PCT/CN2017/076445
Publication Date: 20.09.2018 International Filing Date: 13.03.2017
IPC:
C07D 213/76 (2006.01) ,C07D 213/75 (2006.01) ,A61K 31/444 (2006.01) ,A61K 31/495 (2006.01) ,A61K 31/4418 (2006.01) ,A61P 19/06 (2006.01) ,A61P 19/02 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 13/12 (2006.01) ,A61P 29/00 (2006.01) ,A61P 13/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
76
to which a second hetero atom is attached
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
75
Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4418
having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
06
Antigout agents, e.g. antihyperuricemic or uricosuric agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
04
for urolithiasis
Applicants:
成都海创药业有限公司 HINOVA PHARMACEUTICALS INC. [CN/CN]; 中国四川省成都市 高新区科技园南路5号蓉药大厦4层1号 No. 1, 4rd Floor, RongYao Building A, 5 Keyuan South Road, High-Tech Zone Chengdu, Sichuan 610041, CN
Inventors:
樊磊 FAN, Lei; CN
杜武 DU, Wu; CN
李兴海 LI, Xinghai; CN
陈元伟 CHEN, Yuanwei; CN
胥珂馨 XU, Kexin; CN
陈锞 CHEN, Ke; CN
张少华 ZHANG, Shaohua; CN
罗潼川 LUO, Tongchuan; CN
Agent:
成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY(GENERAL PARTNERSHIP); 中国四川省成都市 高新区衣冠庙邮局A-42号信箱 The Yiguanmiao Post Office Box A-42, Hi-Tech Zone Chengdu, Sichuan 610041, CN
Priority Data:
Title (EN) SULFONAMIDE COMPOUNDS AND PREPARATION METHOD THEREFOR, AND USE OF SAME AS URATE TRANSPORTER INHIBITOR MEDICINES
(FR) COMPOSÉS DE SULFONAMIDE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS INHIBITEURS DU TRANSPORTEUR D'URATE
(ZH) 磺酰胺类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途
Abstract:
(EN) Disclosed are sulfonamide compounds as shown in the formula (A) and the preparation method therefor, and the use of the same as urate transporter inhibitor medicines. Various compounds, and salts, hydrates or solvates thereof provided by the present invention are selective uric acid reabsorption inhibitors, and can treat hyperuricemia and gout by promoting the excretion of uric acid from the human body and by reducing serum uric acid.
(FR) L'invention concerne des composés de sulfonamide tels que représentés par la formule (A), leur procédé de préparation et leur utilisation en tant que médicaments inhibiteurs du transporteur d'urate. Les divers composés, sels, hydrates ou solvates de ceux-ci fournis par la présente invention sont des inhibiteurs sélectifs de réabsorption d'acide urique, qui peuvent traiter l'hyperuricémie et la goutte en favorisant l'excrétion d'acide urique à partir du corps humain et en réduisant l'acide urique sérique.
(ZH) 本发明公开了一类式(A)所示的磺酰胺类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途。本发明提供的各种化合物及其盐类、水合物或溶剂合物,是一种选择性尿酸再吸收抑制剂,可以通过促进尿酸从体内排泄并减少血清尿酸来治疗高尿酸血症和痛风。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)