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1. (WO2018165766) METHOD FOR PURIFICATION OF ALBUMIN
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/165766 International Application No.: PCT/CA2018/050321
Publication Date: 20.09.2018 International Filing Date: 16.03.2018
IPC:
C07K 14/765 (2006.01) ,A61K 38/38 (2006.01) ,C07K 1/30 (2006.01) ,C07K 1/34 (2006.01) ,C07K 1/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
765
Serum albumin, e.g. HSA
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
38
Albumins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
30
by precipitation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
34
by filtration, ultrafiltration or reverse osmosis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
36
by a combination of two or more processes of different types
Applicants: THERAPURE BIOPHARMA INC.[CA/CA]; 2585 Meadowpine Blvd. Mississauga, Ontario L5N 8H9, CA
Inventors: SEO, Jin Seog; CA
MILLER, David; CA
Agent: BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; Scotia Plaza, 40 King Street West 40th Floor Toronto, Ontario M5H 3Y2, CA
Priority Data:
62/472,00716.03.2017US
Title (EN) METHOD FOR PURIFICATION OF ALBUMIN
(FR) PROCÉDÉ DE PURIFICATION D’ALBUMINE
Abstract:
(EN) A method for the purification of albumin from plasma is described. The method comprises (a) contacting the plasma with sodium caprylate (NaCP) at an amount dependent on total protein concentration and the ratio of NaCP to total protein in the plasma, (b) heating the plasma at a near neutral pH range, and (c) separating the albumin from non-albumin-phase. The said method provides for a high yield and purity albumin solution.
(FR) La présente invention concerne un procédé de purification d’albumine à partir de plasma. Le procédé comprend (a) la mise en contact du plasma avec du caprylate sodique (NaCP) sous une quantité dépendante de la concentration totale en protéine et du rapport du NaCP à la protéine totale dans le plasma, (b) le chauffage du plasma sous une plage de pH quasi neutre, et (c) la séparation de l’albumine de la phase non-albumine. Ledit procédé permet d’obtenir un rendement et une pureté de la solution d’albumine élevés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)