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1. (WO2018165711) BIODEGRADABLE DRUG-POLYMER CONJUGATE

Pub. No.:    WO/2018/165711    International Application No.:    PCT/AU2018/050234
Publication Date: Fri Sep 21 01:59:59 CEST 2018 International Filing Date: Thu Mar 15 00:59:59 CET 2018
IPC: A61K 47/50
A61K 31/5575
A61K 31/085
A61K 31/21
A61K 31/47
A61K 31/433
A61P 27/02
Applicants: POLYACTIVA PTY LTD
Inventors: BIRKETT, Stephen, Lonsdale
DONOHUE, Andrew, Craig
D'SOUZA, Asha, Marina
NG, Sarah Man Yee
SULISTIO, Adrian
TAIT, Russell, John
VALADE, David
NAYLOR, Alan
WATLING, Jason
SCULLINO, Carmen, Vittoria
Title: BIODEGRADABLE DRUG-POLYMER CONJUGATE
Abstract:
A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, β-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to do alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.