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1. (WO2018165710) DRUG-POLYMER CONJUGATE

Pub. No.:    WO/2018/165710    International Application No.:    PCT/AU2018/050233
Publication Date: Fri Sep 21 01:59:59 CEST 2018 International Filing Date: Thu Mar 15 00:59:59 CET 2018
IPC: A61K 31/5575
A61K 47/50
A61P 27/02
Applicants: POLYACTIVA PTY LTD
Inventors: BIRKETT, Stephen, Lonsdale
DONOHUE, Andrew, Craig
D'SOUZA, Asha, Marina
NG, Sarah Man Yee
SULISTIO, Adrian
TAIT, Russell, John
VALADE, David
NAYLOR, Alan
WATLING, Jason
Title: DRUG-POLYMER CONJUGATE
Abstract:
A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.