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1. (WO2018165656) SHORT-ACTING HEPARIN-BASED ANTICOAGULANT COMPOUNDS AND METHODS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/165656 International Application No.: PCT/US2018/021986
Publication Date: 13.09.2018 International Filing Date: 12.03.2018
IPC:
A61M 1/36 (2006.01) ,B01D 15/36 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
26
characterised by the separation mechanism
36
involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL[US/US]; Office Of Commercialization And Economic Development 109 Church Street Chapel Hill, NC 27516, US
Inventors: LIU, Jian; US
WANG, Zhangjie; CN
HSIEH, Po-Hung; US
XU, Yongmei; US
Agent: TAYLOR, Arles A.; US
Priority Data:
62/469,64310.03.2017US
Title (EN) SHORT-ACTING HEPARIN-BASED ANTICOAGULANT COMPOUNDS AND METHODS
(FR) COMPOSÉS ANTICOAGULANTS À BASE D'HÉPARINE À COURTE DURÉE D'ACTION ET PROCÉDÉS
Abstract:
(EN) Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.
(FR) La présente invention concerne des composés d'héparine et des analogues synthétiques d'héparine ayant une activité anticoagulante à courte durée d'action. L'invention concerne en outre des procédés de synthèse de tels composés d'héparine, comprenant des voies chimioenzymatiques utilisant des enzymes sulfotransférases. L'invention concerne en outre des procédés de traitement de patients ayant besoin d'une activité anticoagulante.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)