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1. (WO2018165655) ANTIMICROBIAL PEPTIDES AND METHODS OF MAKING AND USING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/165655 International Application No.: PCT/US2018/021985
Publication Date: 13.09.2018 International Filing Date: 12.03.2018
IPC:
C07K 7/08 (2006.01) ,C40B 50/00 (2006.01) ,A61K 38/10 (2006.01) ,A61P 31/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
50
Methods of creating libraries, e.g. combinatorial synthesis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants: THE JOHNS HOPKINS UNIVERSITY[US/US]; 3400 N. Charles Street Baltimore, Maryland 21218, US
Inventors: CHEN, Charles H.; US
ULMSCHNEIDER, Martin B.; US
Agent: CONTRERA, Joseph; US
Priority Data:
62/469,58810.03.2017US
Title (EN) ANTIMICROBIAL PEPTIDES AND METHODS OF MAKING AND USING SAME
(FR) PEPTIDES ANTIMICROBIENS ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract:
(EN) The present invention provides a new methodology combining MD simulations and database-guided high-throughput screening to rationally design pore forming membrane-active peptides. The present inventive methodology is able to allow tuning of a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions. The present inventive methods will ultimately allow de novo design of membrane-active peptides for a wide range of biomedical applications, including for example, antimicrobial agents.
(FR) La présente invention concerne une nouvelle méthodologie combinant des simulations MD et un criblage à haut rendement guidé par base de données pour concevoir de manière rationnelle des peptides à membrane active formant des pores. La méthodologie de la présente invention est capable de permettre l'accord d'une gamme de propriétés structurelles et fonctionnelles telles que la taille des pores et le ciblage sélectif de membranes avec des compositions lipidiques spécifiques. Les procédés de la présente invention permettent finalement la conception de novo de peptides à membrane active pour une large gamme d'applications biomédicales, notamment par exemple des agents antimicrobiens.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)