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1. (WO2018165589) COMPOSITIONS AND METHODS FOR PRODUCING HIGH SECRETED YIELDS OF RECOMBINANT PROTEINS
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Pub. No.: WO/2018/165589 International Application No.: PCT/US2018/021812
Publication Date: 13.09.2018 International Filing Date: 09.03.2018
IPC:
C08H 1/00 (2006.01) ,C12P 21/00 (2006.01) ,D01F 4/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
H
DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
1
Macromolecular products derived from proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
4
Monocomponent artificial filaments or the like of proteins; Manufacture thereof
Applicants:
BOLT THREADS, INC. [US/US]; 5858 Horton Street, Suite 400 Emeryville, CA 94608, US
Inventors:
KITTLESON, Joshua; US
STEVENS, Thomas; US
HILL, Rena; US
PESCE, Carlos, Gustavo; US
BRESLAUER, David; US
WIDMAIER, Daniel; US
Agent:
HURT, Nicholas; US
SHUSTER, Michael, J.; US
KINCH, Mark; US
HUBL, Susan, T.; US
KABLER, Kevin; US
Priority Data:
62/470,14410.03.2017US
Title (EN) COMPOSITIONS AND METHODS FOR PRODUCING HIGH SECRETED YIELDS OF RECOMBINANT PROTEINS
(FR) COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE RENDEMENTS SÉCRÉTÉS ÉLEVÉS DE PROTÉINES RECOMBINÉES
Abstract:
(EN) The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
(FR) La présente divulgation concerne des procédés de production de protéines recombinées, ainsi que des compositions utilisées dans, et produites par lesdits procédés. Plus spécifiquement, la présente divulgation concerne des procédés de production de rendements sécrétés élevés de protéines recombinées, et les compositions ci-décrites comprennent des constructions d'expression, des vecteurs recombinés, et des cellules hôtes recombinées qui comprennent des séquences polynucléotidiques codant pour des protéines fonctionnellement liées à des signaux de sécrétion recombinés qui comprennent le peptide de tête du facteur α d'accouplement (αMF) de Saccharomyces cerevisiae et un peptide signal non-αMF.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)