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1. (WO2018165584) MICROGEL PARTICLES FOR USE IN 3D PRINTING AND 3D CELL GROWTH MEDIUM AND RELATED COMPOSITIONS, SYSTEMS, AND METHODS

Pub. No.:    WO/2018/165584    International Application No.:    PCT/US2018/021804
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: C08F 220/06
C08F 2/38
C08F 220/56
Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
Inventors: SAWYER, Wallace, Gregory
PARK, Sangwoo
O'BRYAN, Christopher, S.
KABB, Christopher, P.
SUMERLIN, Brent, S.
ANGELINI, Thomas, Ettor
Title: MICROGEL PARTICLES FOR USE IN 3D PRINTING AND 3D CELL GROWTH MEDIUM AND RELATED COMPOSITIONS, SYSTEMS, AND METHODS
Abstract:
Microgel particles for use in a three-dimensional cell growth medium are described. The microgel particles may be swellable and may have properties conducive to improved function and health of cells distributed within the three-dimensional cell growth medium. Related compositions, systems, and methods are also described. Also provided is a plurality of microgel particles and a liquid cell culture medium, wherein the microgel particles are swelled with the liquid cell culture medium to form a granular gel. Also provided is a method of preparing a three-dimensional cell growth medium is disclosed. The method may comprise: mixing a plurality of microgel particles, such as those described above, in a liquid cell culture medium. Also provided is a method of placing cells in a three-dimensional cell growth medium is disclosed. Also provided is a method of synthesizing a protein is disclosed.