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1. (WO2018165516) COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS

Pub. No.:    WO/2018/165516    International Application No.:    PCT/US2018/021689
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: A61K 31/501
A61K 31/433
A61P 35/00
C07D 417/02
C07D 417/14
Applicants: CALITHERA BIOSCIENCES, INC.
Inventors: BROMLEY, Susan, D.
PARLATI, Francesco
GROSS, Matthew, I.
ORFORD, Keith
Title: COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS
Abstract:
The invention relates to methods of treating cancer or myeloproliferative diseases with a combination of a glutaminase inhibitor and a second anticancer agent such as osimertinib, pazopanib, navitoclax, palbociclib, or olaparib. The invention further relates to methods of treating cancer or myeloproliferative diseases with a combination of a glutaminase inhibitor and conventional radiotherapy or stereotactic body radiotherapy.