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1. (WO2018165465) DNA ORIGAMI NANOSTRUCTURES FOR TREATMENT OF ACUTE KIDNEY INJURY
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Pub. No.: WO/2018/165465 International Application No.: PCT/US2018/021599
Publication Date: 13.09.2018 International Filing Date: 08.03.2018
IPC:
A61K 48/00 (2006.01) ,A61P 13/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
Applicants:
YAN, Hao [CN/US]; US
JIANG, Dawei [CN/US]; US
GE, Zhilei [CN/US]; US
IM, Hyung-jun [KR/KR]; KR
ENGLAND, Christopher [US/US]; US
PENG, Huang [CN/CN]; CN
FAN, Chunhai [CN/CN]; CN
CAI, Weibo [US/US]; US
Inventors:
YAN, Hao; US
JIANG, Dawei; US
GE, Zhilei; US
IM, Hyung-jun; KR
ENGLAND, Christopher; US
PENG, Huang; CN
FAN, Chunhai; CN
CAI, Weibo; US
Agent:
KARRI KUENZLI, Bradley; US
Priority Data:
62/469,06409.03.2017US
Title (EN) DNA ORIGAMI NANOSTRUCTURES FOR TREATMENT OF ACUTE KIDNEY INJURY
(FR) NANOSTRUCTURES D'ORIGAMI ADN POUR LE TRAITEMENT D'UNE LÉSION RÉNALE AIGUË
Abstract:
(EN) Disclosed herein are methods of treating acute kidney injury. The method can include administering a sufficient amount of a DNA origami nanostructure to a subject afflicted with AKI to increase an excretory function of said subject. In some examples, the DNA origami nanostructure includes a scaffold strand and a plurality of staple strands, in which the scaffold strand comprises a Ml 3 viral genome having a length of 7249 base pairs; and each staple strand of the plurality of staple strands has a length of about 20 to 60 base pairs.
(FR) L'invention concerne des méthodes de traitement d'une lésion rénale aiguë. La méthode peut comprendre l'administration d'une quantité suffisante d'une nanostructure d'origami ADN à un sujet atteint d'AKI en vue d'augmenter une fonction excrétoire dudit sujet. Dans certains exemples, la nanostructure d'origami ADN comprend un brin échafaudage et une pluralité de brins agrafes, le brin échafaudage comprenant un génome viral Ml 3 ayant une longueur de 7 249 paires de bases ; et chaque brin agrafe de la pluralité de brins agrafes a une longueur d'environ 20 à 60 paires de bases.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)