Search International and National Patent Collections

1. (WO2018165440) DEVICES, SYSTEMS, AND METHODS FOR SPECIMEN PREPARATION AND ANALYSIS USING CAPILLARY AND CENTRIFUGAL FORCES

Pub. No.:    WO/2018/165440    International Application No.:    PCT/US2018/021567
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Fri Mar 09 00:59:59 CET 2018
IPC: B01L 3/00
G01N 33/487
C12Q 1/70
Applicants: NORTHWESTERN UNIVERSITY
Inventors: KELSO, David M.
ELGHANIAN, Robert
Title: DEVICES, SYSTEMS, AND METHODS FOR SPECIMEN PREPARATION AND ANALYSIS USING CAPILLARY AND CENTRIFUGAL FORCES
Abstract:
Provided herein are devices, systems, and methods for specimen preparation by employing a combination of capillary and centrifugal forces, along with the addition of reagents at specified steps, followed by on-device sample analysis. For example, provided herein are devices, and methods of use thereof, that collect a sample by capillary force, separate components of the collected sample by centrifugal force, isolate one or more of the separated components by a second application of capillary force, mix the separated components with a first reagent from a storage compartment under centrifugal force, and continue to advance the materials through the device by alternating capillary and centrifugal forces, optionally with the addition of additional reagents from additional storage compartments, until final materials reach a test zone of the device for analysis.