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1. (WO2018165432) FUNCTIONALIZATION OF POLYMER SCAFFOLDS

Pub. No.:    WO/2018/165432    International Application No.:    PCT/US2018/021554
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Fri Mar 09 00:59:59 CET 2018
IPC: C08G 64/42
C12N 9/96
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: SHEA, Lonnie, D.
SKOUMAL, Michael
PEARSON, Ryan, M.
Title: FUNCTIONALIZATION OF POLYMER SCAFFOLDS
Abstract:
The disclosure provides a method of preparing a polymer scaffold including admixing a biotinylated reagent and a polymer to form a biotinylated polymer, subjecting the biotinylated polymer to conditions sufficient to form the polymer scaffold and optionally admixing the polymer scaffold with a streptavidin-modified biomolecule to form a biomolecule-modified polymer scaffold. The disclosure further provides a method of preparing a polymer scaffold including admixing a first click chemistry reagent and a poly(lactic-co-glycolic acid) (PLGA) polymer to form a modified PLGA polymer, subjecting the modified PLGA polymer to conditions sufficient to form the polymer scaffold, and optionally admixing the polymer scaffold with a biomolecule modified to include a second click chemistry reagent that selectively reacts with the first click chemistry reagent, to form a biomolecule-modified polymer scaffold.