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1. (WO2018165331) METHOD AND APPARATUS FOR ORDERED NANOPLASMONIC SENSOR FORMATION THROUGH MICROFLUIDIC ASSEMBLY
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Pub. No.: WO/2018/165331 International Application No.: PCT/US2018/021392
Publication Date: 13.09.2018 International Filing Date: 07.03.2018
IPC:
G01N 21/552 (2014.01) ,G01N 33/48 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/553 (2006.01) ,G01N 33/574 (2006.01) ,B82Y 15/00 (2011.01)
[IPC code unknown for G01N 21/552]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
551
the carrier being inorganic
553
Metal or metal coated
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
15
Nano-technology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
Applicants:
THE TRUSTEES OF DARTMOUTH COLLEGE [US/US]; 11 Rope Ferry Road, Room 6210 Hanover, New Hampshire 03755, US
Inventors:
TADIMETY, Amogha; US
ZHANG, John X.J.; US
Agent:
VOCK, Curtis; US
ANIS, Hissan; US
BARONE, Stephen B.; US
BARTON, Steven K.; US
LINK, Douglas; US
COUGHLIN, Sean M.; US
CURTIS, Michael J.; US
DECONTI, Giulio A.; US
DIZEREGA, Philip; US
CHAPMAN, Gary B.; US
JEFFRIES, James H.; US
LAMBRECHTS, Robert J.; US
POPLIN, Alan J.; US
CHEN, Xiaoyue (Peter); US
TRINQUE, Brian C.; US
VELEMA, James H.; US
SMITH, Mary Breen; US
WILKINS, Andrew T.; US
WASHINGTON, Michele N.; US
VICKERY, Neal S.; US
STONE-HULSLANDER, Judith; US
ALTER, Scott M.; US
DELANEY, Marie J.; US
SULLIVAN, Sally A.; US
MORIARTY, Gordon R.; US
MACK, Brian R.; US
Priority Data:
62/468,49908.03.2017US
Title (EN) METHOD AND APPARATUS FOR ORDERED NANOPLASMONIC SENSOR FORMATION THROUGH MICROFLUIDIC ASSEMBLY
(FR) PROCÉDÉ ET APPAREIL DE FORMATION D'UN CAPTEUR NANOPLASMONIQUE ORDONNÉ DANS UN ENSEMBLE MICROFLUIDIQUE
Abstract:
(EN) A method of making a plasmon-resonance biosensor includes conjugating precious metal nanorods with form factor at least 1.5 with a biological probe material. Microfluidic chambers of volume under 0.025 microliter are formed over a substrate, and an aqueous suspension of the conjugated nanorods is injected into the chambers. The nanorods are organized in rows and aligned in long dimension along the rows. The biosensor is configured to be read by obtaining an optical absorption spectrum upon exposure to the analyte. The biosensor includes precious metal nanorods organized in rows with long dimension approximately parallel to the rows. The nanorods are conjugated with biological probes capable of binding to an analyte, the probes may be an aptamer, an antibody, a protein-nucleic acid (PNA), a complimentary DNA, or an enzyme having a binding site.
(FR) L'invention concerne un procédé de fabrication d'un biocapteur à résonance plasmonique, qui consiste à conjuguer des nanotiges de métal précieux présentant un facteur de forme d'au moins 1,5 avec un matériau de sonde biologique. Des chambres microfluidiques de volume inférieur à 0,025 microlitre sont formées sur un substrat, et une suspension aqueuse des nanotiges conjuguées est injectée dans les chambres. Les nanotiges sont organisées en rangées, et alignées dans la dimension longue le long des rangées. Le biocapteur est conçu pour être lu par l'obtention d'un spectre d'absorption optique lorsqu'il est exposé à l'analyte. Le biocapteur comprend des nanotiges de métal précieux organisées en rangées, dont la dimension longue est approximativement parallèle aux rangées. Les nanotiges sont conjuguées à des sondes biologiques capables de se lier à un analyte, les sondes peuvent être un aptamère, un anticorps, une protéine-acide nucléique (PNA), un ADN complémentaire ou une enzyme comportant un site de liaison.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)