Search International and National Patent Collections

1. (WO2018165186) ASSESSMENT OF CHRONIC IRON DEFICIENCY

Pub. No.:    WO/2018/165186    International Application No.:    PCT/US2018/021189
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Wed Mar 07 00:59:59 CET 2018
IPC: A61K 33/26
A61K 38/17
A61K 39/395
A61P 3/00
G01N 33/53
G01N 33/68
Applicants: INTRINSIC LIFESCIENCES LLC
CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: WESTERMAN, Mark
FLEMING, Mark D.
Title: ASSESSMENT OF CHRONIC IRON DEFICIENCY
Abstract:
The present application relates to methods of using humanized antibodies that specifically bind to hepcidin to quantify hepcidin in a fluid sample. Another aspect relates to discriminating, using quantified plasma hepcidin levels, between a subject with a condition due to biallelic TMPRSS6 mutation and other chronic iron deficiency/iron deficiency anemia. Another aspect relates to methods of treatment of a disease or condition related to hepcidin comprising use of humanized antibodies which bind hepcidin to determine hepcidin levels in the subject.