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1. (WO2018165159) METHODS AND SYSTEMS FOR CELL-FREE BIODISCOVERY OF NATURAL PRODUCTS

Pub. No.:    WO/2018/165159    International Application No.:    PCT/US2018/021146
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Wed Mar 07 00:59:59 CET 2018
IPC: C07K 1/00
C12P 19/34
C12P 21/00
C12P 21/02
Applicants: SYNVITROBIO, INC.
Inventors: SUN, Zachary Z.
MANSFIELD, Richard
CHIAO, Abel
TREGO, Kelly
Title: METHODS AND SYSTEMS FOR CELL-FREE BIODISCOVERY OF NATURAL PRODUCTS
Abstract:
Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more organisms such as bacteria, archaea, plant or animal; a plurality of supplements for gene expression; an energy recycling system for providing adenosine triphosphate and recycling adenosine diphosphate; and an engineered propeptide operably linked to a stabilizing domain. Methods for making and using the same are also provided.