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1. (WO2018165145) PHARMACEUTICAL FORMULATIONS COMPRISING 5-CHLORO-N4-[2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL} PYRIMIDINE-2,4-DIAMINE
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Pub. No.: WO/2018/165145 International Application No.: PCT/US2018/021128
Publication Date: 13.09.2018 International Filing Date: 06.03.2018
IPC:
A61K 9/20 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 9/20][IPC code unknown for A61K 31/506][IPC code unknown for A61P 35]
Applicants:
ARIAD PHARMACEUTICALS, INC. [US/US]; 40 Landsdowne Street Cambridge, MA 02139, US
Inventors:
VERWIJS, Dauntel, S.; US
DESAI, Samir; US
SHARMA, Pradeep, K.; US
ROZAMUS, Leonard, W.; US
WILLIAMSON, Jeff; US
CARTWRIGHT, Danica; US
VED, Parag; US
Agent:
RIEGER, Dale; US
YANG, Kunyong; US
YEUNG, Constance; US
STEINBERG-TATMAN, Galina; US
COLE, Maya; US
Priority Data:
62/468,69608.03.2017US
62/491,17927.04.2017US
62/569,95409.10.2017US
Title (EN) PHARMACEUTICAL FORMULATIONS COMPRISING 5-CHLORO-N4-[2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL} PYRIMIDINE-2,4-DIAMINE
(FR) FORMULATIONS PHARMACEUTIQUES COMPRENANT UNE 5-CHLORO-N4-[2-(DIMÉTHYLPHOSPHORYL)PHÉNYL]-N2-{2-MÉTHOXY-4-[4-(4-MÉTHYLPIPÉRAZIN-1-YL)PIPÉRIDIN-1-YL]PHÉNYL}PYRIMIDINE-2,4-DIAMINE
Abstract:
(EN) This invention relates to a pharmaceutical composition comprising 5-chloro-N4-[2- (dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1- yl]phenyl}pyrimidine-2,4-diamine as the active pharmaceutical ingredient, and therapeutic uses of the pharmaceutical formulation. In particular, the invention is directed to tablets comprising the pharmaceutical composition, methods of preparing the tablets, and therapeutic uses thereof.
(FR) La présente invention concerne une composition pharmaceutique comprenant une 5-chloro-N4-[2-(diméthylphosphoryl)phényl]-N2-{2-méthoxy-4-[4-(4-méthylpipérazin-1-yl)pipéridin-1-yl]phényl}pyrimidine-2,4-diamine à titre de substance pharmaceutique active (API), et ses utilisations thérapeutiques. En particulier, l'invention concerne des comprimés comprenant ladite composition pharmaceutique, des procédés de préparation desdits comprimés, et leurs utilisations thérapeutiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)