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1. (WO2018165112) BICYCLIC COMPOUND AND USE THEREOF FOR INHIBITING HISTONE METHYLTRANSFERASE
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Pub. No.: WO/2018/165112 International Application No.: PCT/US2018/021079
Publication Date: 13.09.2018 International Filing Date: 06.03.2018
IPC:
A61K 31/496 (2006.01) ,A61K 31/497 (2006.01) ,A61P 15/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
14
for lactation disorders, e.g. galactorrhoea
Applicants:
ONCOTHERAPY SCIENCE, INC. [JP/JP]; 2-1, Sakado 3-chome, Takatsu-ku Kawasaki-shi, Kanagawa 213-0012, JP
Inventors:
RAVULA, Srinivas; IN
SIVALENKA, Vijayasaradhi; IN
MANTIPALLY, Manohar; IN
PATNAIK, Praveen; IN
DUPATI, Praveen; IN
CHAKRABARTI, Anjan; SG
NAKAMURA, Yusuke; JP
MATSUO, Yo; JP
MIYAMOTO, Takashi; JP
OKAMOTO, Yasuhide; JP
DUAN, Zhiyong; US
Agent:
BASTIAN, Kevin L.; US
JEWIK, Patrick R.; US
Priority Data:
62/469,31909.03.2017US
Title (EN) BICYCLIC COMPOUND AND USE THEREOF FOR INHIBITING HISTONE METHYLTRANSFERASE
(FR) COMPOSÉ BICYCLIQUE ET SON UTILISATION POUR INHIBER L’HISTONE MÉTHYLTRANSFÉRASE
Abstract:
(EN) The present invention relates to a compound represented by formula (I), a method for the preparation thereof, and a pharmaceutical composition containing the compound as an active ingredient for inhibiting histone methyltransferase such as SUV39H2.
(FR) La présente invention concerne un composé représenté par la formule (I), un procédé pour sa préparation, et une composition pharmaceutique contenant le composé en tant que principe actif pour inhiber l'histone méthyltransférase telle que SUV39H2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)