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1. (WO2018164876) NOVEL FUNGAL FUCOSIDASES AND THEIR USE IN PREVENTING AND/OR TREATING A PATHOGENIC INFECTION IN AN ANIMAL
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Pub. No.: WO/2018/164876 International Application No.: PCT/US2018/019845
Publication Date: 13.09.2018 International Filing Date: 27.02.2018
IPC:
A61P 31/00 (2006.01) ,C12N 9/24 (2006.01) ,A23L 33/10 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
[IPC code unknown for A23L 33/10]
Applicants: DUPONT NUTRITION BIOSCIENCES APS[DK/DK]; Langebrogade 1 DK-1411 Copenhagen K, DK
E.I. DU PONT DE NEMOURS AND COMPANY[US/US]; Chestnut Run Plaza 974 Centre Road P. O. BOX 2915 Wilmington, Delaware 19805, US (SC)
Inventors: ZHANG, Zhenghong; CN
Agent: CHRISTENBURY, Lynne M.; US
Priority Data:
PCT/CN2017/07574306.03.2017CN
Title (EN) NOVEL FUNGAL FUCOSIDASES AND THEIR USE IN PREVENTING AND/OR TREATING A PATHOGENIC INFECTION IN AN ANIMAL
(FR) NOUVELLES FUCOSIDASES FONGIQUES ET LEUR UTILISATION DANS LA PRÉVENTION ET/OU LE TRAITEMENT D'UNE INFECTION PATHOGÈNE CHEZ UN ANIMAL
Abstract:
(EN) Disclosed are methods and compositions using glycoside hydrolases, such as an alpha-L-fucosidases, to prevent and/or treat a pathogenic infection and/or diarrhea in an animal wherein the pathogenic infection is caused by a pathogen capable of binding to an animal intestinal cell wherein said binding of the pathogen is dependent on the presence of a pathogen binding site having at least one glycan structure substituted with at least one alpha-1,2-L-fucose moiety comprising administering to the animal an effective amount of a glycoside hydrolase capable of removing the at least one alpha-1,2-L-fucose moiety from the pathogen binding site.
(FR) La présente invention concerne des méthodes et des compositions utilisant des glycoside hydrolases, telles que des alpha-L-fucosidases, pour prévenir et/ou traiter une infection pathogène et/ou la diarrhée chez un animal, l'infection pathogène étant provoquée par un agent pathogène apte à se lier à une cellule intestinale animale, ladite liaison de l'agent pathogène dépendant de la présence d'un site de liaison de l'agent pathogène ayant au moins une structure glycane substituée par au moins une fraction alpha-1,2-L-fucose, comprenant l'administration à l'animal d'une quantité efficace d'une glycoside hydrolase apte à éliminer ladite ou lesdites fractions alpha-1,2-L-fucose du site de liaison de l'agent pathogène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)