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1. (WO2018164580) BIOMARKERS FOR CELLULAR SENESCENCE

Pub. No.:    WO/2018/164580    International Application No.:    PCT/NL2018/050148
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: G01N 33/50
Applicants: RIJKSUNIVERSITEIT GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
Inventors: DEMARIA, Marco
HERNANDEZ-SEGURA, Alejandra
Title: BIOMARKERS FOR CELLULAR SENESCENCE
Abstract:
The invention relates to biomarkers and uses thereof, in particular to a set of proteins or mRNAs that provides a significant indication as to whether a cell is senescent or not. Provided is the use of a biomarker panel comprising six or more polypeptides, or their encoding mRNA's, wherein the panel comprises at least the biomarkers TSPAN13, GDNF, C2CD5, SUSD6, BCL2L2, PLK3, or a variant or fragment thereof, as a biomarker set for cellular senescence. Also provided is a senescent cell detection kit for detecting senescent cells, and a drug conjugate for killing a senescent cell.