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1. (WO2018164502) COMPOSITION FOR REMOVING NOISE FROM MRI AND PAD USING SAME
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Pub. No.: WO/2018/164502 International Application No.: PCT/KR2018/002757
Publication Date: 13.09.2018 International Filing Date: 08.03.2018
IPC:
A61K 49/06 (2006.01) ,A61B 5/055 (2006.01) ,G01R 33/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
05
Measuring for diagnosis by means of electric currents or magnetic fields
055
involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
28
Details of apparatus provided for in groups G01R33/44-G01R33/6496
32
Excitation or detection systems, e.g. using radiofrequency signals
34
Constructional details, e.g. resonators
Applicants:
국립암센터 NATIONAL CANCER CENTER [KR/KR]; 경기도 고양시 일산동구 일산로 323 (마두동) (Madu-dong) 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, KR
Inventors:
박경석 PARK, Kyung Seok; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2017-003007709.03.2017KR
10-2017-006036416.05.2017KR
Title (EN) COMPOSITION FOR REMOVING NOISE FROM MRI AND PAD USING SAME
(FR) COMPOSITION POUR ÉLIMINER LE BRUIT D'UNE IRM ET TAMPON L'UTILISANT
(KO) MRI 노이즈 제거용 조성물 및 이를 이용한 패드
Abstract:
(EN) The present invention relates to a composition for removing noise from an MRI, including a compound containing a hydrogen bond, and a pad using the same. The present invention has the advantages of naturally generating high signals through indirect energy exchange due to magnetization of the hydrogen bond, and activating an image of tissue which was unable to be embodied as an image due to noise generated by metal. Also, the composition according to the present invention can be applied by a non-invasive method unlike an MRI contrast agent, and thus there is no problem that will cause side effects in the human body, and the composition is not toxic and thus is safe. In addition, the composition is used in the manner of covering an area requiring diagnosis or being attached to an MRI apparatus, and thus has the advantages of improving images of a relatively wide range, and obtaining more accurate image information than restoration of a distorted image by a program. At the same time, the composition according to the present invention is expected to be easily commercialized in companies because costs required to manufacture the composition are low.
(FR) La présente invention concerne une composition pour éliminer le bruit d'une IRM, comprenant un composé contenant une liaison hydrogène, et un tampon l'utilisant. La présente invention présente les avantages de générer naturellement des signaux élevés par échange d'énergie indirect en raison de la magnétisation de la liaison hydrogène, et d'activer une image de tissu qui était incapable de se matérialiser sous la forme d'une image en raison du bruit généré par le métal. Également, la composition selon la présente invention peut être utilisée par un procédé non invasif contrairement à un agent de contraste IRM, et donc il n'y a pas de problème qui provoquera des effets secondaires dans le corps humain, et la composition n'est pas toxique et est donc sûre. De plus, la composition est utilisée de manière à recouvrir une zone nécessitant un diagnostic ou étant fixée à un appareil IRM, et présente ainsi les avantages d'améliorer des images d'une plage relativement large, et d'obtenir des informations d'image plus précises que la restauration d'une image déformée par un programme. En même temps, la composition selon la présente invention est censée être facilement commercialisée dans les sociétés car les coûts nécessaires à la fabrication de la composition sont faibles.
(KO) 본 발명은 수소결합이 포함된 화합물을 포함하는 MRI 노이즈 제거용 조성물 및 이를 이용한 패드에 관한 것으로서, 수소결합의 자화에 따른 간접적인 에너지 교환을 통하여 자연적으로 높은 신호를 발생시키고 금속으로 인해 발생하는 노이즈에 의해 영상으로 구현되지 못한 조직의 영상을 활성화시킬 수 있는 장점이 있다. 또한, 본 발명에 따른 조성물은 MRI 조영물과 달리 비침습적인 방법에 의해 적용할 수 있어 인체에 부작용을 초래할 문제가 없으며, 독성이 없어 안전하다. 또한, 진단이 필요한 영역에 덮거나 MRI 장치에 부착되는 방법에 의하여 이용되어 비교적 넓은 범위의 영상을 개선할 수 있고, 프로그램에 의해 왜곡된 영상을 복원하는 것보다 정확한 영상정보를 획득할 수 있는 장점이 있다. 동시에 본 발명에 따른 조성물은 그 제조에 비용이 적게 소요되어 기업에서 용이하게 제품화할 수 있을 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)