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1. (WO2018164290) COMPOSITION FOR SKIN AGING MEASUREMENT, PREVENTION, OR ALLEVIATION, USING HAPLN1

Pub. No.:    WO/2018/164290    International Application No.:    PCT/KR2017/002395
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Tue Mar 07 00:59:59 CET 2017
IPC: G01N 33/68
C12Q 1/68
G01N 33/50
A61K 38/17
A61K 31/728
A61K 8/64
A61K 8/73
A61Q 19/08
A23L 33/17
Applicants: CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION
중앙대학교 산학협력단
Inventors: KIM, Dae Kyong
김대경
FU, Zhicheng
부지성
BACK, Moon Jung
백문정
Title: COMPOSITION FOR SKIN AGING MEASUREMENT, PREVENTION, OR ALLEVIATION, USING HAPLN1
Abstract:
The present invention relates to an HAPLN1 protein of an aged individual. The HAPLN1 protein has reduced expression during aging and has an excellent effect of alleviating and reversing skin aging including wrinkles when administered. Therefore, by using the difference in the expression, provided are: a biomarker composition for measuring skin aging, capable of diagnosing skin aging; a kit; and a method for screening for skin aging-alleviating agents, comprising a step of detecting the expression level of an HAPLN1 protein or an HAPLN1 gene. In addition, provided are a skin aging preventing or alleviating pharmaceutical composition, cosmetic composition, or health functional food, and a wrinkle alleviating cosmetic composition or health functional food, all of which contain any one or more selected from the group consisting of an HAPLN1 protein, a gene coding for the same, and an effective agent for promoting the expression of the HAPLN1 protein or gene or activating the functions thereof.