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1. (WO2018162944) RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR
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Pub. No.: WO/2018/162944 International Application No.: PCT/IB2017/051275
Publication Date: 13.09.2018 International Filing Date: 04.03.2017
IPC:
C07K 16/28 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ZHANG, Ying [CN/CN]; CN
XIANGTAN TENGHUA BIOSCIENCE [CN/CN]; Room 1907, 19th Floor of Innovation and Enterpreneurship Building No 9 DongFeng Road Xiangtan Jiuhua Economic and Technological Developmental district Xiangtan, Hunan, CN
Inventors:
ZHANG, Ying; CN
Priority Data:
Title (EN) RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR
(FR) ANTICORPS RECOMBINANTS DIRIGÉS CONTRE LA MORT PROGRAMMÉE 1 (PD-1) ET LEURS UTILISATIONS
Abstract:
(EN) Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.
(FR) L'invention concerne un anticorps monoclonal, en particulier un anticorps recombinant de lapin, qui se lie spécifiquement à la PD-1 humaine avec des fonctions biologiques et une très haute affinité, et des méthodes d'utilisation. Selon certains modes de réalisation, les anticorps sont des anticorps complètement humanisés qui se lient à la PD-1 humaine. L'invention concerne également des molécules d'acide nucléique codant pour les anticorps et des méthodes d'expression des anticorps. Dans certains modes de réalisation, les anticorps sont utiles pour inhiber ou neutraliser l'activité de la PD-1, ce qui fournit un moyen de traitement, de prévention et/ou de diagnostic d'une maladie ou d'une affection comme un cancer ou une infection virale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)