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1. (WO2018162928) METHOD FOR RESTORING EFFICACY OF AN ANTIBACTERIAL AGENT
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Pub. No.: WO/2018/162928 International Application No.: PCT/GB2018/050613
Publication Date: 13.09.2018 International Filing Date: 09.03.2018
IPC:
C07K 7/62 (2006.01) ,A61K 38/12 (2006.01) ,A61K 31/05 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50
Cyclic peptides containing at least one abnormal peptide link
54
with at least one abnormal peptide link in the ring
60
the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
62
Polymyxins; Related peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
Applicants:
HELPERBY THERAPEUTICS LIMITED [GB/GB]; 66 Lincoln's Inn Fields London Greater London WC2A 3LH, GB
Inventors:
COATES, Anthony; GB
HU, Yanmin; GB
Agent:
BATEMAN, Rachel; GB
Priority Data:
1703898.510.03.2017GB
1802249.112.02.2018GB
Title (EN) METHOD FOR RESTORING EFFICACY OF AN ANTIBACTERIAL AGENT
(FR) PROCÉDÉ DE RESTAURATION DE L'EFFICACITÉ D'UN AGENT ANTIBACTÉRIEN
Abstract:
(EN) The invention provides a method for restoring efficacy of an antibacterial agent, the method comprising (i) combining the antibacterial agent with a first antibiotic resistance breaker after a first time period; and (ii) combining the antibacterial agent with a second antibiotic resistance breaker after a second time period, wherein during each time period the efficacy of the antibacterial agent decreases due to increasing antibiotic resistance, and wherein each antibiotic resistance breaker at least partially restores the efficacy of the antibacterial agent relative to the end of the preceding time period. The first and second antibiotic resistance breakers have different mechanisms of action. Additionnally the invention provides the use of at least two antibiotic resistance breakers to prolong the efficacy of an antibacterial agent, wherein the at least two antibiotic resistance breakers have different mechanisms of action.
(FR) L'invention concerne un procédé pour restaurer l'efficacité d'un agent antibactérien, le procédé comprenant (i) la combinaison de l'agent antibactérien avec un premier agent de rupture de résistance aux antibiotiques après une première période de temps ; et (ii) la combinaison de l'agent antibactérien avec un second agent de rupture de résistance aux antibiotiques après une seconde période de temps, pendant chaque période de temps, l'efficacité de l'agent antibactérien diminue en raison de l'augmentation de la résistance aux antibiotiques, et chaque agent de rupture de résistance aux antibiotiques restaure au moins partiellement l'efficacité de l'agent antibactérien par rapport à la fin de la période de temps précédente. Les premier et second agents de rupture de résistance aux antibiotiques ont différents mécanismes d'action. L'invention concerne également l'utilisation d'au moins deux agents de rupture de résistance aux antibiotiques pour prolonger l'efficacité d'un agent antibactérien, lesdits au moins deux agents de rupture de résistance aux antibiotiques ayant différents mécanismes d'action.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)