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1. (WO2018162696) COMMON GENETIC VARIATIONS AT THE TCRA-TCRD LOCUS CONTROL THYMIC FUNCTION IN HUMANS

Pub. No.:    WO/2018/162696    International Application No.:    PCT/EP2018/055873
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: C12Q 1/6883
A61K 35/12
Applicants: INSTITUT PASTEUR
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Inventors: TOUBERT, Antoine
CLAVE, Emmanuel
LESTON ARAUJO, Itaua
ALBERT, Matthew
QUINTANA MURCI, Lluis
ALANIO, Cécile
Title: COMMON GENETIC VARIATIONS AT THE TCRA-TCRD LOCUS CONTROL THYMIC FUNCTION IN HUMANS
Abstract:
The invention relates to a method of evaluating thymic function in a subject comprising the detection of a genetic polymorphism in the T-cell receptor alpha-T cell receptor delta (TCRA-TCRD) locus associated with the level of T lymphocyte production by the thymus. The invention relates also to the use of said method and genetic polymorphism for the diagnostic, prognostic, treatment or monitoring of conditions or clinical situations where thymopoiesis is impacted, or that are impacted by thymopoiesis efficiency and/or quality.