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|1. (WO2018162696) COMMON GENETIC VARIATIONS AT THE TCRA-TCRD LOCUS CONTROL THYMIC FUNCTION IN HUMANS|
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
LESTON ARAUJO, Itaua
QUINTANA MURCI, Lluis
|Title:||COMMON GENETIC VARIATIONS AT THE TCRA-TCRD LOCUS CONTROL THYMIC FUNCTION IN HUMANS|
The invention relates to a method of evaluating thymic function in a subject comprising the detection of a genetic polymorphism in the T-cell receptor alpha-T cell receptor delta (TCRA-TCRD) locus associated with the level of T lymphocyte production by the thymus. The invention relates also to the use of said method and genetic polymorphism for the diagnostic, prognostic, treatment or monitoring of conditions or clinical situations where thymopoiesis is impacted, or that are impacted by thymopoiesis efficiency and/or quality.