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1. (WO2018162329) HPPD VARIANTS AND METHODS OF USE

Pub. No.:    WO/2018/162329    International Application No.:    PCT/EP2018/055101
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Fri Mar 02 00:59:59 CET 2018
IPC: C12N 9/02
C12N 15/82
Applicants: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
BAYER CROPSCIENCE LP
Inventors: LINKA, Marc
POREE, Fabien
LABER, Bernd
LANGE, Gudrun
THIES, Christina
WEBER, Ernst
STRERATH, Michael
GESKE, Sandra
BALVEN-ROSS, Heike
WOBST, Nina
COCO, Wayne
PAWLOWSKI, Nikolaus
TEBBE, Jan
DUBALD, Manuel
Title: HPPD VARIANTS AND METHODS OF USE
Abstract:
In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.