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1. (WO2018161976) TETRAPEPTIDE PROPYLENE OXIDE DERIVATIVE, PREPARATION METHOD THERFOR, AND USE THEREOF

Pub. No.:    WO/2018/161976    International Application No.:    PCT/CN2018/086030
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Wed May 09 01:59:59 CEST 2018
IPC: C07K 7/06
C07K 5/107
C07K 5/103
C07K 5/117
C07K 1/06
A61K 38/08
A61K 38/07
A61P 29/00
A61P 35/00
A61P 37/02
Applicants: NANJING LINGRUI PHARMACEUTICAL TECHNOLOGY CO., LTD
南京陵瑞医药科技有限公司
Inventors: ZHU, Yongqiang
朱永强
LEI, Meng
雷萌
ZHANG, Haoyang
张浩洋
DU, Xiao
杜晓
Title: TETRAPEPTIDE PROPYLENE OXIDE DERIVATIVE, PREPARATION METHOD THERFOR, AND USE THEREOF
Abstract:
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene oxide derivative or the pharmaceutically acceptable salt thereof is shown in formula (I). The compound of the present invention can selectively inhibit the chymotrypsin-like activity of 20S proteasome, and is also expected to display anti-inflammatory properties and inhibition of cell proliferation.