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|1. (WO2018161976) TETRAPEPTIDE PROPYLENE OXIDE DERIVATIVE, PREPARATION METHOD THERFOR, AND USE THEREOF|
|Applicants:||NANJING LINGRUI PHARMACEUTICAL TECHNOLOGY CO., LTD
|Title:||TETRAPEPTIDE PROPYLENE OXIDE DERIVATIVE, PREPARATION METHOD THERFOR, AND USE THEREOF|
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene oxide derivative or the pharmaceutically acceptable salt thereof is shown in formula (I). The compound of the present invention can selectively inhibit the chymotrypsin-like activity of 20S proteasome, and is also expected to display anti-inflammatory properties and inhibition of cell proliferation.