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1. (WO2018161922) COMPOUND HAVING PRMT5 INHIBITORY ACTIVITY, PREPARATION FOR COMPOUND, AND APPLICATIONS THEREOF
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Pub. No.: WO/2018/161922 International Application No.: PCT/CN2018/078308
Publication Date: 13.09.2018 International Filing Date: 07.03.2018
IPC:
C07D 495/04 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国上海市 浦东张江祖冲之路555号 555 Zu Chong Zhi Road, Zhang Jiang, Pudong Shanghai 201203, CN
Inventors:
段文虎 DUAN, Wenhu; CN
罗成 LUO, Cheng; CN
邵敬伟 SHAO, Jingwei; CN
朱孔凯 ZHU, Kongkai; CN
张元元 ZHANG, Yuanyuan; CN
丁宏 DING, Hong; CN
蒋华良 JIANG, Hualiang; CN
Agent:
上海一平知识产权代理有限公司 XU AND PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1 Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710138381.309.03.2017CN
Title (EN) COMPOUND HAVING PRMT5 INHIBITORY ACTIVITY, PREPARATION FOR COMPOUND, AND APPLICATIONS THEREOF
(FR) COMPOSÉ AYANT UNE ACTIVITÉ INHIBITRICE DE PRMT5, PRÉPARATION POUR COMPOSÉ ET APPLICATIONS ASSOCIÉES
(ZH) 一种具有PRMT5抑制活性的化合物及其制备和应用
Abstract:
(EN) The present invention relates to a compound having PRMT5 inhibitory activity, a preparation for the compound, and applications thereof. Specifically, the compound of the present invention has a structure as represented by formula I, where the definitions of the groups and substituents are as presented in the description. Also disclosed are a preparation method for the compound and uses thereof in preventing and/or treating cancer-related diseases. The compound of the present invention has great protein arginine N-methyltransferase 5 inhibitory activity and thus is applicable in preparing a series of medicaments for treating diseases related to protein arginine N-methyltransferase 5 activity.
(FR) La présente invention concerne un composé ayant une activité inhibitrice de PRMT5, une préparation pour le composé et des applications associées. Particulièrement, le composé de la présente invention possède une structure telle que représentée par la formule I, dans laquelle les définitions des groupes et des substituants sont telles que présentées dans la description. L'invention concerne également un procédé de préparation du composé et ses utilisations dans la prévention et/ou le traitement de maladies liées au cancer. Le composé de l'invention présente une activité inhibitrice élevée de l'arginine N-méthyltransférase 5 et peut donc être utilisé dans la préparation d'une série de médicaments pour le traitement de maladies liées à l'activité de l'arginine N-méthyltransférase 5.
(ZH) 本发明涉及一种具有PRMT5抑制活性的化合物及其制备和应用。具体地,本发明化合物具有式I所示结构,其中各基团和取代基的定义如说明书中所述。本发明还公开了所述化合物的制备方法及其在预防和/或治疗癌症相关疾病方面的用途。本发明化合物具有优异的精氨酸甲基转移酶5抑制活性,故能够用于制备一系列治疗与精氨酸甲基转移酶5活性相关的疾病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)