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|1. (WO2018161892) BENZENE SULFONAMIDE IDO1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF|
|Applicants:||CHINA PHARMACEUTICAL UNIVERSITY
|Title:||BENZENE SULFONAMIDE IDO1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF|
A benzene sulfonamide compound having structural features of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Experimental results indicate that the compound has a significant inhibitory effect on activities of IDO1, and can effectively promote the proliferation of T cells, inhibit the differentiation of naïve T cells into regulatory T cells, and reverse IDO1-mediated immunosuppression, being able to be used in the treatment of related diseases having pathological features of IDO1-mediated kynurenine metabolic pathways, including cancers, viral infections, neurodegenerative diseases, cataracts, organ transplant rejection, depression, autoimmune diseases and the like.