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1. (WO2018161876) DIHYDROQUINOXALINE BROMODOMAIN RECOGNITION PROTEIN INHIBITOR, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2018/161876    International Application No.:    PCT/CN2018/078051
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Tue Mar 06 00:59:59 CET 2018
IPC: C07D 403/10
C07D 417/10
C07D 403/14
C07D 487/22
C07D 491/107
C07D 487/04
C07D 413/10
A61K 31/498
A61K 31/541
A61P 35/00
A61P 37/00
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors: XIONG, Bing
熊兵
SHEN, Jingkang
沈竞康
MIAO, Zehong
缪泽鸿
HU, Jianping
胡剑萍
WANG, Yingqing
王迎庆
SONG, Shanshan
宋姗姗
MENG, Tao
孟韬
Title: DIHYDROQUINOXALINE BROMODOMAIN RECOGNITION PROTEIN INHIBITOR, PREPARATION METHOD AND USE THEREOF
Abstract:
The present invention relates to a dihydroquinoxaline bromodomain recognition protein inhibitor, a preparation method and a use thereof. The inhibitor of the present invention is a compound represented by general formula (I), or a stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate and crystal form thereof. The definition of each substituent is as described in the description and claims. The compound represented by general formula (I) of the present invention may inhibit a bromodomain recognition protein and may be used for preparing a drug which regulates the apparent state of cells and treats a series of diseases and symptoms which are mediated by the bromodomain recognition protein.