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1. (WO2018161872) ANTI-B7-H3 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL USE THEREOF

Pub. No.:    WO/2018/161872    International Application No.:    PCT/CN2018/078011
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Tue Mar 06 00:59:59 CET 2018
IPC: C07K 16/28
C12N 1/19
C12N 1/21
C12N 5/18
C12N 5/22
C12N 15/13
C12N 15/63
A61K 39/395
A61P 35/00
C12R 1/19
C12R 1/84
C12R 1/91
Applicants: JIANGSU HENGRUI MEDICINE CO., LTD.
江苏恒瑞医药股份有限公司
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD
上海恒瑞医药有限公司
Inventors: YAN, Shude
闫树德
GE, Hu
葛虎
ZHANG, Lianshan
张连山
CAO, Guoqing
曹国庆
Title: ANTI-B7-H3 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL USE THEREOF
Abstract:
Provided are an anti-B7-H3 antibody, an antigen-binding fragment thereof, and a pharmaceutical composition comprising the antibody or the antigen-binding fragment. Also provided is a use of the antibody or the antigen-binding fragment in preparation of a drug for treating a B7-H3 mediated disease or disorder. The antibody can be a murine antibody, a chimeric antibody, a humanized antibody, or a human antibody. The pharmaceutical composition can be used for treating cancers.