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1. (WO2018161418) HUMANIZED MOUSE MODEL FOR HEPATITIS B CONSTRUCTED BY USING STEM CELLS AND APPLICATION THEREOF

Pub. No.:    WO/2018/161418    International Application No.:    PCT/CN2017/081751
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Tue Apr 25 01:59:59 CEST 2017
IPC: C12N 5/071
A01K 67/027
Applicants: ZHEJIANG UNIVERSITY
浙江大学
Inventors: LI, Jun
李君
LI, Jiang
李江
SUN, Suwan
孙苏婉
LI, Lanjuan
李兰娟
XIA, Ningshao
夏宁邵
CHENG, Tong
程通
YUAN, Lunzhi
袁伦志
Title: HUMANIZED MOUSE MODEL FOR HEPATITIS B CONSTRUCTED BY USING STEM CELLS AND APPLICATION THEREOF
Abstract:
Provided are a humanized mouse model for hepatitis B constructed by using stem cells and an application thereof. The humanized mouse model for hepatitis B is constructed by means of obtaining human stem cells, implanting the human stem cells into a mouse with liver damage such that 1*104^8 transplanted human stem cells exist within the mouse body, and like steps; the present invention may be used in research on antiviral drug resistance, research on the pathogenesis of chronic hepatitis B, and like directions.