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1. (WO2018161168) CURCUMIN-BASED COMPOSITIONS & METHODS OF USE THEREOF

Pub. No.:    WO/2018/161168    International Application No.:    PCT/CA2018/050275
Publication Date: Fri Sep 14 01:59:59 CEST 2018 International Filing Date: Fri Mar 09 00:59:59 CET 2018
IPC: A61K 31/12
A61P 3/06
C07C 43/295
Applicants: CAVALERI, Franco
Inventors: CAVALERI, Franco
Title: CURCUMIN-BASED COMPOSITIONS & METHODS OF USE THEREOF
Abstract:
Methods for increasing LDL receptor levels in a plurality of cells are disclosed. For example, the methods include providing to the cells a curcumin composition that is at least 15% curcumin II or at least 5% curcumin III, in order to increase LDL receptor levels. In addition, compositions for increasing LDL receptor levels in a plurality of cells are disclosed, which include a curcumin composition consisting of at least 15% curcumin II or at least 5% curcumin III (or combinations of such curcuminoids), along with a pharmaceutically-acceptable solvent, filler, or carrier. Still further, methods for decreasing MSK1 levels in a plurality of cells are disclosed, which involve administering a curcumin Ill- enriched composition to the cells.