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1. (WO2018161009) AAV-MEDIATED DIRECT IN VIVO CRISPR SCREEN IN GLIOBLASTOMA

Pub. No.:    WO/2018/161009    International Application No.:    PCT/US2018/020729
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Sat Mar 03 00:59:59 CET 2018
IPC: C12N 9/22
C12N 15/10
C12N 15/11
C12N 15/63
C12N 15/86
C12N 15/90
C12N 15/861
C12Q 1/68
C12Q 1/6809
Applicants: YALE UNIVERSITY
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: CHEN, Sidi
CHOW, Ryan
GUZMAN, Christopher D.
PLATT, Randall J.
Title: AAV-MEDIATED DIRECT IN VIVO CRISPR SCREEN IN GLIOBLASTOMA
Abstract:
The present invention includes novel compositions and methods for identifying driver mutations in glioblastoma. In one aspect, the invention includes an AAV-CRISPR library for identifying driver mutations in, and thus treatments for glioblastoma.