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1. (WO2018160920) SYSTEMS AND METHODS OF ASSISTED REPRODUCTION AND PREVENTION OF GENETIC DEFECTS IN OFFSPRING USING INDUCED PLURIPOTENT STEM CELLS

Pub. No.:    WO/2018/160920    International Application No.:    PCT/US2018/020578
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Sat Mar 03 00:59:59 CET 2018
IPC: C12N 5/07
C12N 5/071
C12N 5/073
C12N 5/0735
C12N 15/873
Applicants: ORIG3N, INC.
Inventors: SMITH, Robin Y.
GLICKSMAN, Marcie A.
Title: SYSTEMS AND METHODS OF ASSISTED REPRODUCTION AND PREVENTION OF GENETIC DEFECTS IN OFFSPRING USING INDUCED PLURIPOTENT STEM CELLS
Abstract:
Reserves of immortalized genetic material are stored in a bank for providing a resource (e.g., artificial gametes) for couples (e.g., same sex couples) to produce biologically-related children. The reserves provide the ability to derive sperm from induced pluripotent stem cells (iPSCs) of one partner and/or eggs from iPSCs of the other partner. For example, a biological sample is stored as iPSCs that can be used to generate an unlimited supply of genetic material (e.g., artificial gametes for conception) when needed by a user (e.g., a year or more after the sample is provided, e.g., 5 years or more after the sample is provided). Such a bank is helpful for an individual in a same sex (or infertile) couple who desires to have biological children at some point during his/her lifetime, but does not plan to have children in the immediate timeframe, for example.