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1. (WO2018160772) METHOD OF TREATING OBESITY, INSULIN RESISTANCE, NON-ALCOHOLIC FATTY LIVER DISEASE INCLUDING NON-ALCOHOLIC STEATOHEPATITIS
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Pub. No.: WO/2018/160772 International Application No.: PCT/US2018/020333
Publication Date: 07.09.2018 International Filing Date: 28.02.2018
IPC:
A61K 45/00 (2006.01) ,A61P 3/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
GONZALEZ, Frank, J. [US/US]; US (US)
XIE, Cen [CN/US]; US (US)
JIANG, Changtao [CN/CN]; CN (US)
THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES [US/US]; Office Of Technology Transfer 6011 Executive Blvd. Suite 325 Rockville, MD 20852, US
Inventors:
GONZALEZ, Frank, J.; US
XIE, Cen; US
JIANG, Changtao; CN
Agent:
ZERHUSEN, Bryan, D.; US
FENN, Edward, A.; US
MCCUE, Patrick, P.; US
NGUYEN-ANTCZAK, Lauren; US
FERGUSON, Steven; US
Priority Data:
62/465,00928.02.2017US
Title (EN) METHOD OF TREATING OBESITY, INSULIN RESISTANCE, NON-ALCOHOLIC FATTY LIVER DISEASE INCLUDING NON-ALCOHOLIC STEATOHEPATITIS
(FR) PROCÉDÉ DE TRAITEMENT DE L'OBÉSITÉ, DE LA RÉSISTANCE À L'INSULINE, D'UNE STÉATOSE HÉPATIQUE NON ALCOOLIQUE COMPRENANT UNE STÉATOHÉPATITE NON ALCOOLIQUE
Abstract:
(EN) The method disclosed herein provides a treatment for obesity, insulin resistance, non¬ alcoholic fatty acid disease and non-alcoholic steatohepatitis in a subject, comprising selectively decreasing the expression or inhibiting the activity of HIF-2a in the intestine, thereby decreasing obesity, insulin resistance, and non-alcoholic fatty acid disease in the subject.
(FR) Le procédé selon l'invention concerne un traitement de l'obésité, de la résistance à l'insuline, de la stéatose hépatique non alcoolique et de la stéatohépatite non alcoolique chez un sujet, comprenant la réduction sélective de l'expression ou l'inhibition de l'activité de HIF-2a dans l'intestin, réduisant ainsi l'obésité, la résistance à l'insuline et la stéatose hépatique non alcoolique chez le sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)