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1. (WO2018160717) COMPOUNDS AND METHODS FOR TREATING CANCER

Pub. No.:    WO/2018/160717    International Application No.:    PCT/US2018/020257
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: C07K 16/28
G01N 33/574
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: VON ROEMELING, Christina
TUN, Han W.
COPLAND III, John A.
CAULFIELD, Thomas R.
KIM, Yon Son Betty
Title: COMPOUNDS AND METHODS FOR TREATING CANCER
Abstract:
The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.