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1. (WO2018160675) METHODS FOR DIAGNOSING, PROGNOSING, AND TREATING COLORECTAL CANCER USING BIOMARKER EXPRESSION

Pub. No.:    WO/2018/160675    International Application No.:    PCT/US2018/020191
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: C12P 19/34
C12Q 1/68
C40B 40/06
Applicants: BAYLOR RESEARCH INSTITUTE
Inventors: GOEL, Ajay
KANDIMALLA, Raju
TODEN, Shusuke
ROY, Roshni
OZAWA, Tsuyoshi
MATSUYAMA, Takatoshi
WENG, Wenhao
Title: METHODS FOR DIAGNOSING, PROGNOSING, AND TREATING COLORECTAL CANCER USING BIOMARKER EXPRESSION
Abstract:
Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major clinical challenge in cancer treatment is to identify the subset of patients who will benefit from a therapeutic regimen, both in metastatic and adjuvant settings. The number of anti-cancer drugs and multi-drug combinations has increased substantially in the past decade, however, treatments continue to be applied empirically using a trial-and-error approach. Here methods and compositions are provided to determine the optimal treatment option for cancer patients.