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1. (WO2018160654) ADJUVANT TREATMENT OF HER2-POSITIVE BREAST CANCER

Pub. No.:    WO/2018/160654    International Application No.:    PCT/US2018/020154
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: C07K 16/32
A61P 35/00
A61K 9/00
A61K 45/06
A61K 39/395
A61K 39/00
Applicants: GENENTECH, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: BENYUNES, Mark, C.
ROSS, Graham, Alexander
Title: ADJUVANT TREATMENT OF HER2-POSITIVE BREAST CANCER
Abstract:
Methods are provided for the adjuvant treatment of operable HER2-positive primary breast cancer in human patients by administration of pertuzumab in addition to chemotherapy and trastuzumab. The methods reduce the risk of recurrence of invasive breast cancer or death for a patient diagnosed with HER2-positive early breast cancer (eBC) compared to administration of trastuzumab and chemotherapy, without pertuzumab.