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1. (WO2018160637) DRUG COMBINATIONS FOR CEREBROVASCULAR DISEASE

Pub. No.:    WO/2018/160637    International Application No.:    PCT/US2018/020125
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: A61K 31/19
A61K 31/135
A61P 9/10
A61P 25/28
Applicants: BIOCHEMPHARM, LLC
Inventors: KATZ, Bryan, J.
Title: DRUG COMBINATIONS FOR CEREBROVASCULAR DISEASE
Abstract:
The invention provides a drug combination of at least two compounds selected from the group consisting of Valproate, Ketamine, Tacrolimus, Clevidipine and Joro Spider Toxin that can be administered parenterally or orally to patients over 18 years of age at the onset of stroke symptoms or Transient Ischemic Attack (TIA). The drug combination may be administered regardless of stroke etiology (ischemic vs. hemorrhagic); may be given up to 6 hours following the onset of stroke and should not interfere with the subsequent action of thrombolytic agents such as tPA (Tissue Plasminogen Activator).