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|1. (WO2018160573) INFLUENZA VACCINES BASED ON AAV VECTORS|
|Applicants:||THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
JANSSEN BIOTECH, INC.
|Inventors:||LIMBERIS, Maria P.
TRETIAKOVA, Anna P.
WILSON, James M.
|Title:||INFLUENZA VACCINES BASED ON AAV VECTORS|
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.