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1. (WO2018160573) INFLUENZA VACCINES BASED ON AAV VECTORS

Pub. No.:    WO/2018/160573    International Application No.:    PCT/US2018/019974
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Wed Feb 28 00:59:59 CET 2018
IPC: C07K 16/10
C12N 7/00
C12N 15/86
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
JANSSEN BIOTECH, INC.
Inventors: LIMBERIS, Maria P.
TRETIAKOVA, Anna P.
WILSON, James M.
NASO, Michael
KOLKMAN, Joost
FRIESEN, Robert
WANG, Qiang
Title: INFLUENZA VACCINES BASED ON AAV VECTORS
Abstract:
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.