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1. (WO2018160539) MAYTANSINOID DERIVATIVES WITH SELF-IMMOLATIVE PEPTIDE LINKERS AND CONJUGATES THEREOF
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Pub. No.: WO/2018/160539 International Application No.: PCT/US2018/019874
Publication Date: 07.09.2018 International Filing Date: 27.02.2018
IPC:
A61K 47/65 (2017.01) ,A61K 47/68 (2017.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 47/65][IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451, US
Inventors:
WIDDISON, Wayne, C.; US
Agent:
LU, Yu; US
BAI, Mei; US
BLAZESKI, George; US
BELT, Erik, P.; US
BOWLES, Anita, M.; US
Priority Data:
62/465,11828.02.2017US
62/480,20931.03.2017US
Title (EN) MAYTANSINOID DERIVATIVES WITH SELF-IMMOLATIVE PEPTIDE LINKERS AND CONJUGATES THEREOF
(FR) DÉRIVÉS DE MAYTANSINOÏDES COMPRENANT DES LIEURS PEPTIDIQUES AUTO-IMMOLABLES ET CONJUGUÉS CORRESPONDANTS
Abstract:
(EN) The invention relates to novel cell-binding agent-maytansinoid conjugate having a self-immolative peptide linker and more specifically to conjugates of formula (I). The invention also provides novel maytansinoid compounds of formula (II), (III), (IV) or (V). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
(FR) L'invention concerne un nouveau conjugué agent de liaison cellulaire-maytansinoïde, qui possède des lieurs peptidiques auto-immolables et, plus particulièrement, des conjugués de la formule (I). L'invention concerne également de nouveaux composés de maytansinoïdes de formule (II), (III), (IV) ou (V). L'invention concerne en outre des compositions et procédés utiles pour inhiber une croissance cellulaire anormale ou pour traiter un trouble prolifératif chez un mammifère à l'aide des composés ou conjugués de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)