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1. (WO2018160027) MULTI-DOMAIN VESICLE COMPRISING IMMUNOSUPPRESSIVE FACTOR CONTROL MATERIAL, PRODUCTION METHOD THEREFOR AND IMMUNOMODULATORY COMPOSITION COMPRISING SAME
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Pub. No.: WO/2018/160027 International Application No.: PCT/KR2018/002517
Publication Date: 07.09.2018 International Filing Date: 02.03.2018
IPC:
A61K 9/50 (2006.01) ,A61K 9/127 (2006.01) ,A61K 9/107 (2006.01) ,A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
단디바이오사이언스 주식회사 DANDI BIOSCIENCE INC [KR/KR]; 서울시 광진구 능동로 120, 304호 (화양동, 의생명과학연구관) (Hwayang-dong, Biomedical Science Bldg.) 304ho, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, KR
Inventors:
임용택 LIM, Yong Taik; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2017-002730302.03.2017KR
10-2018-002490128.02.2018KR
Title (EN) MULTI-DOMAIN VESICLE COMPRISING IMMUNOSUPPRESSIVE FACTOR CONTROL MATERIAL, PRODUCTION METHOD THEREFOR AND IMMUNOMODULATORY COMPOSITION COMPRISING SAME
(FR) VÉSICULE MULTIDOMAINE COMPRENANT UNE MATIÈRE DE RÉGULATION DE FACTEUR IMMUNOSUPPRESSEUR, SON PROCÉDÉ DE PRODUCTION, ET COMPOSITION IMMUNOMODULATRICE LA COMPRENANT
(KO) 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물
Abstract:
(EN) The present invention relates to a multi-domain vesicle comprising an immunosuppressive factor control material, a production method for the multi-domain vesicle and an immunomodulatory composition comprising the multi-domain vesicle. According to one aspect of the present invention, the multi-domain vesicle comprises: at least two liposomes making contact and connected with each other; and a multi-domain vesicle outer wall surrounding the at least two liposomes. The multi-domain vesicle is formed from an oil phase and an aqueous phase, wherein: the oil phase comprises a first immunomodulatory material and a fluid oil; the oil phase forms a membrane of the liposomes, and the multi-domain vesicle outer wall; the aqueous phase comprises a second immunomodulatory material; the aqueous phase is an internal aqueous phase of the membrane of the liposomes, and an outer aqueous phase of the membrane of the liposomes; the first immunomodulatory material and the second immunomodulatory material are immunosuppressive factor control materials; and the fluid oil increases the structural stability of the at least two liposomes making contact and connected with each other.
(FR) La présente invention concerne une vésicule multidomaine comprenant une matière de régulation de facteur immunosuppresseur, un procédé de production de la vésicule multidomaine, et une composition immunomodulatrice comprenant la vésicule multidomaine. Selon un aspect de la présente invention, la vésicule multidomaine comprend : au moins deux liposomes qui entrent en contact et sont reliés l'un à l'autre ; et une paroi externe de vésicule multidomaine entourant les au moins deux liposomes. La vésicule multidomaine est formée à partir d'une phase huileuse et d'une phase aqueuse ; la phase huileuse comprenant une première matière immunomodulatrice et une huile fluide ; la phase huileuse formant une membrane des liposomes, et la paroi externe de vésicule multidomaine ; la phase aqueuse comprenant une seconde matière immunomodulatrice ; la phase aqueuse étant une phase aqueuse interne de la membrane des liposomes, et une phase aqueuse externe de la membrane des liposomes ; la première matière immunomodulatrice et la seconde matière immunomodulatrice étant des matières de régulation de facteur immunosuppresseur ; et l'huile fluide augmentant la stabilité structurale des au moins deux liposomes qui entrent en contact et sont reliés l'un à l'autre.
(KO) 본 발명은, 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 상기 다중도메인캡슐의 제조방법, 및 상기 다중도메인캡슐을 포함하는 면역조절 조성물에 관한 것으로, 본 발명의 일 측면에 따르면 서로 접촉하고 연결되어 있는 둘 이상의 리포좀, 및 상기 둘 이상의 리포좀을 둘러싸는 다중도메인캡슐 외벽을 포함하는 다중도메인캡슐로서, 상기 다중도메인캡슐은 유기상과 수용액상으로 이루어지고, 상기 유기상은 제1면역조절물질 및 유동성 오일을 포함하며, 상기 유기상은 상기 리포좀의 멤브레인, 및 상기 다중도메인캡슐 외벽을 형성하고, 상기 수용액상은 제2면역조절물질을 포함하며, 상기 수용액상은 상기 리포좀 멤브레인의 내부 수용액상 및 리포좀 멤브레인의 외부 수용액상이며, 상기 제1면역조절물질, 및 제2면역조절물질은 면역억제인자 제어물질이고, 상기 유동성 오일은 서로 접촉하고 연결되어 있는 둘 이상의 리포좀의 구조 안정성을 향상시키는 것을 특징으로 하는, 다중도메인캡슐이 제공될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)