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1. (WO2018159702) MEDICINE

Pub. No.:    WO/2018/159702    International Application No.:    PCT/JP2018/007583
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: A61K 31/472
A61J 1/05
A61K 9/08
A61K 31/4725
A61K 47/04
A61K 47/10
A61P 27/02
A61P 27/06
B65D 1/00
B65D 65/20
Applicants: KOWA COMPANY, LTD.
Inventors: YAMAKITA, Yoshihiro
山北 佳央
The present invention establishes a technology for stably formulating an isoquinoline-6-amino derivative as an ophthalmic agent or the like. Provided is a medicinal preparation that is obtained by housing, in a polyester-based resin container or polyolefin-based resin container, an aqueous composition containing a compound represented by general formula (1) (in the formula: R1 and R2 each independently represent a hydrogen atom or a C1-C4 alkyl group; R3 represents a hydrogen atom or a hydroxyl group; "A" denotes -CH(R4)- or -CH2-CH(R4)-(here, R4 is an optionally substituted C6-C10 aryl group or an optionally substituted 5 to 10-membered heteroaryl group); and formula (1) also includes a tautomer thereof) or a salt thereof, or a solvate thereof.