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1. (WO2018159427) TWO-PHASE REACTION MEDIUM USING 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL AND ALIPHATIC HYDROCARBON-BASED SOLVENT

Pub. No.:    WO/2018/159427    International Application No.:    PCT/JP2018/006337
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Fri Feb 23 00:59:59 CET 2018
IPC: C07C 31/38
C07C 5/31
C07C 15/60
C07C 17/358
C07C 25/22
C07B 61/00
C07C 9/15
C07C 13/18
C07C 13/50
Applicants: CENTRAL GLASS COMPANY, LIMITED
セントラル硝子株式会社
Inventors: ICHIKAWA, Junji
市川 淳士
FUJITA, Takeshi
藤田 健志
TAKAHASHI, Ikko
高橋 一光
Title: TWO-PHASE REACTION MEDIUM USING 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL AND ALIPHATIC HYDROCARBON-BASED SOLVENT
Abstract:
This two-phase reaction medium for an organic reaction includes: a first liquid phase which uses 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) as a solvent; and a second liquid phase comprising a solvent that is essentially incompatible with the HFIP and that has an aliphatic hydrocarbon, preferably a C5-30 aliphatic hydrocarbon (the aliphatic hydrocarbon being straight-chain, branched-chain or cyclic, and in which a portion of the C-C bonds thereof may form double or triple bonds), or a combination thereof as main components (meaning that the solvent includes these components in a ratio of 50% or greater). Through use of the two-phase reaction medium, it is possible to realize a novel reaction system whereby undesired secondary reactions can be suppressed while the reactivity-promoting effect of the HFIP solvent in an organic reaction is maintained. In particular, when the two-phase reaction medium is used, the yield of the object substance in a phenacene synthesis reaction by “intramolecular hydroarylation of an inert alkyne” is markedly enhanced relative to a case in which HFIP alone is used as the solvent.