Search International and National Patent Collections
|1. (WO2018159427) TWO-PHASE REACTION MEDIUM USING 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL AND ALIPHATIC HYDROCARBON-BASED SOLVENT|
|Applicants:||CENTRAL GLASS COMPANY, LIMITED
|Title:||TWO-PHASE REACTION MEDIUM USING 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL AND ALIPHATIC HYDROCARBON-BASED SOLVENT|
This two-phase reaction medium for an organic reaction includes: a first liquid phase which uses 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) as a solvent; and a second liquid phase comprising a solvent that is essentially incompatible with the HFIP and that has an aliphatic hydrocarbon, preferably a C5-30 aliphatic hydrocarbon (the aliphatic hydrocarbon being straight-chain, branched-chain or cyclic, and in which a portion of the C-C bonds thereof may form double or triple bonds), or a combination thereof as main components (meaning that the solvent includes these components in a ratio of 50% or greater). Through use of the two-phase reaction medium, it is possible to realize a novel reaction system whereby undesired secondary reactions can be suppressed while the reactivity-promoting effect of the HFIP solvent in an organic reaction is maintained. In particular, when the two-phase reaction medium is used, the yield of the object substance in a phenacene synthesis reaction by “intramolecular hydroarylation of an inert alkyne” is markedly enhanced relative to a case in which HFIP alone is used as the solvent.