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|1. (WO2018159089) PROTEIN CRYSTALLIZATION METHOD AND CRYSTALLIZATION DEVICE|
CONFOCAL SCIENCE INC.
|Title:||PROTEIN CRYSTALLIZATION METHOD AND CRYSTALLIZATION DEVICE|
Provided are: an economically superior protein crystallization method that can efficiently identify conditions for crystallization using a small amount of a protein; and a crystallization device used in this method. According to the present invention, a part of a transparent sealed vessel 1 is formed of a molecular weight cut-off semipermeable membrane 2 that lets a precipitating agent pass through but blocks a protein. The transparent sealed vessel is filled with a solution of the protein, and then a precipitating agent solution, obtained by changing the concentration and/or pH of the precipitating agent, is supplied to the semipermeable membrane 2 in a continuous manner so that the protein is crystallized by the precipitating agent that permeates into the sealed vessel 1 through the semipermeable membrane 2.