Search International and National Patent Collections

1. (WO2018159028) N-BENZYL-2-BROMO-3-METHOXYPROPIONAMIDE AND METHOD FOR PRODUCING INTERMEDIATE THEREOF

Pub. No.:    WO/2018/159028    International Application No.:    PCT/JP2017/041899
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Wed Nov 22 00:59:59 CET 2017
IPC: C07C 231/12
C07C 51/56
C07C 57/04
C07C 231/02
C07C 233/05
C07C 233/09
C07C 235/06
Applicants: API CORPORATION
株式会社エーピーアイ コーポレーション
Inventors: NAGAHAMA, Masaki
長濱 正樹
SAITO, Kenta
齋藤 健太
Title: N-BENZYL-2-BROMO-3-METHOXYPROPIONAMIDE AND METHOD FOR PRODUCING INTERMEDIATE THEREOF
Abstract:
The present invention provides an industrially excellent production method by which N-benzyl-2-bromo-3-methoxypropionamide can be safely produced in high yield at lower cost. The production method of the present application comprises, in the following order, an amidation step in which diacrylic anhydride is reacted with benzylamine in a solvent to obtain N-benzylacrylamide, a bromination step in which the N-benzylacrylamide is reacted with bromine in a solvent to obtain N-benzyl-2,3-dibromopropionamide, and a methoxylation step in which the N-benzyl-2,3-dibromopropionamide is reacted with methanol in the presence of a base to obtain N-benzyl-2-bromo-3-methoxypropionamide.