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1. (WO2018158727) TGF-Β-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF

Pub. No.:    WO/2018/158727    International Application No.:    PCT/IB2018/051320
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Fri Mar 02 00:59:59 CET 2018
IPC: C07K 19/00
A61K 38/16
A61P 35/00
C07K 14/71
C07K 16/00
C12N 15/62
C12N 5/10
C12P 21/02
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA
Inventors: LENFERINK, Anne E.G.
ZWAAGSTRA, John C.
SULEA, Traian
O'CONNOR-MCCOURT, Maureen D.
Title: TGF-Β-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF
Abstract:
The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-β) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.