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1. (WO2018158697) A PROCESS FOR THE PREPARATION OF IXAZOMIB CITRATE

Pub. No.:    WO/2018/158697    International Application No.:    PCT/IB2018/051268
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: C07D 233/60
C07F 5/02
Applicants: FRESENIUS KABI ONCOLOGY LIMITED
Inventors: PANDEY, Maneesh Kumar
SHUKLA, Sonu Prasad
TIWARI, Raj Narayan
SOKHI, Sarbjot Singh
SINGH, Govind
LAHIRI, Saswata
CABRI, Walter
Title: A PROCESS FOR THE PREPARATION OF IXAZOMIB CITRATE
Abstract:
The present invention relates to a process for the preparation of compound of formula (I), wherein, R1 and R2 are each independently hydroxy, alkoxy, aryloxy, or aralkoxy; or R1 and R2 together form a moiety derived from an alpha-hydroxy carboxylic acid compound or a beta-hydroxy carboxylic acid compound, wherein the atom attached to boron in each case is an oxygen atom; or R1 and R2 together form the boronate esters of boronic acid.