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1. (WO2018158646) RIFAXIMIN CRYSTALLINE FORM
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Pub. No.: WO/2018/158646 International Application No.: PCT/IB2018/050920
Publication Date: 07.09.2018 International Filing Date: 15.02.2018
IPC:
C07D 498/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
22
in which the condensed system contains four or more hetero rings
Applicants:
GRANULES INDIA LIMITED [IN/IN]; My Home Hub, 2nd Floor, 3rd Block, Madhapur, Hyderabad Telangana 500081, IN
Inventors:
VNKV VETUKURI, Prasada Raju; IN
VEDANTHAM, Ravindra; IN
BOINI, Ambaiah; IN
GILLA, Goverdhan; IN
KANUPARTHY, Rama Seshaiah; IN
CHATURVEDI, Akshay Kant; IN
Priority Data:
20174100737702.03.2017IN
Title (EN) RIFAXIMIN CRYSTALLINE FORM
(FR) FORME CRISTALLINE DE LA RIFAXIMINE
Abstract:
(EN) The present invention relates to a process for the preparation of crystalline Form GR of Rifaximin (I). The invention also relates to crystalline Form GR of Rifaximin obtained by the process of the present invention, the said Form GR being substantially pure, stable, and characterized by X- ray powder diffraction pattern comprising of atleast five 2θ° peaks selected form 5.5, 6.6, 6.8, 7.5, 7.7, 11.8, 13.3 and 15.4 ± 0.2 2θ°. The present invention further relates to process for the preparation of substantially pure Rifaximin comprising recrystallization using mixture of alcoholic solvents.
(FR) La présente invention concerne un procédé de préparation de la forme cristalline GR de la Rifaximine. L'invention concerne également sur la forme cristalline GR de la Rifaximine obtenue par le procédé selon la présente invention, ladite forme GR étant pratiquement pure, stable et caractérisée par un diagramme de diffraction des rayons X sur poudre comprenant au moins cinq pics de 2θ° choisis parmi 5,5, 6,6, 6,8, 7,5, 7,7, 11,8, 13,3, et 15,4 ± 0,2 2θ°. La présente invention concerne en outre un procédé de préparation de la Rifaximine sensiblement pure comprenant une recristallisation à l'aide d'un mélange de solvants alcooliques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)