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1. (WO2018158583) URINARY TRACT INFECTION DIAGNOSTIC

Pub. No.:    WO/2018/158583    International Application No.:    PCT/GB2018/050535
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Fri Mar 02 00:59:59 CET 2018
IPC: G01N 33/569
Applicants: MOLOGIC LIMITED
Inventors: PAREKH, Gita
DAVIS, Paul
THOMPSON, Julie
DUVOIX, Annelyse
Title: URINARY TRACT INFECTION DIAGNOSTIC
Abstract:
Method for detecting a urinary tract infection (UTI) in a subject comprising determining levels of one or more biomarkers selected from MMP8, HNE,Cystatin C, MMP9, HSA, IL-8, interleukin-6 (IL-6),interleukin-1 beta (IL-1b), fibrinogen, RBP4, active MMP9 and MMP2, NGAL, Desmosine, MPO and CRP in a urine sample obtained from the subject. The determined levels may then be compared with a threshold level, wherein increased levels of at least one of the biomarkers in the urine sample relative to the threshold level is indicative of the presence of a urinary tract infection. Methods for monitoring a UTI and monitoring treatment of a UTI are also provided as are companion systems or test kits.